Flower

The Whip / Whip It

(MAC 1 x Cookies and Cream)

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Bred by Capulator and selected by @Tahoe_Nugz, this strain combines rare genetics and was originally made popular under the names Miracle Whip and The Whip. This exotic cross of MAC 1 and Cookies and Cream will leave your nose and taste buds begging for more. Sometimes even more trichome-covered than MAC 1, the aroma and flavor of Whip It are like creamy, sweet, tangy, cookies with a hint of citrus. Some of our cultivators have also described Whip It as tasting like a lime creamsicle, and this description certainly applies to extracts, which strengthen and accentuate the strain’s more nuanced flavors. Whip it is an ideal hybrid for daytime activities.

Indica: 50%

Sativa: 50%

Terpenes:

Ocimene

Proven to be useful in defense against pests, ocimene can be found in several plants like basil, parsley, tarragon, and orchids. Like many other terpenes, ocimene is often used commercially for its sweet, floral, and herbaceous aroma. Although research is relatively limited, studies utilizing essential oils rich in ocimene isomers have shown promising results for various conditions. For example, one study[1] demonstrated the potential anti-inflammatory and antioxidant properties of this terpene. Another study[2] showed promising results for the use of ocimene to treat hypertension and diabetes. Several other studies have exhibited other useful properties of this terpene, including possible anti-bacterial[3], anti-fungal[4], anticonvulsant[5], and anti-tumor[6] applications.

[1] Karimian P, Kavoosi G, Amirghofran Z. Anti-oxidative and anti-inflammatory effects of Tagetes minuta essential oil in activated macrophages. Asian Pac J Trop Biomed. 2014 Mar;4(3):219-27. doi: 10.1016/S2221-1691(14)60235-5. PMID: 25182441; PMCID: PMC3868793.

[2] Oboh G, Ademosun AO, Odubanjo OV, Akinbola IA. Antioxidative properties and inhibition of key enzymes relevant to type-2 diabetes and hypertension by essential oils from black pepper. Adv Pharmacol Sci. 2013;2013:926047. doi: 10.1155/2013/926047. Epub 2013 Nov 21. PMID: 24348547; PMCID: PMC3856121.

[3] Mohadjerani M, Hosseinzadeh R, Hosseini M. Chemical composition and antibacterial properties of essential oil and fatty acids of different parts of Ligularia persica Boiss. Avicenna J Phytomed. 2016 May-Jun;6(3):357-65. PMID: 27462560; PMCID: PMC4930544.

[4] Ali NA, Sharopov FS, Al-Kaf AG, Hill GM, Arnold N, Al-Sokari SS, Setzer WN, Wessjohann L. Composition of essential oil from Tagetes minuta and its cytotoxic, antioxidant and antimicrobial activities. Nat Prod Commun. 2014 Feb;9(2):265-8. PMID: 24689306.

[5] Sayyah M, Nadjafnia L, Kamalinejad M. Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil. J Ethnopharmacol. 2004 Oct;94(2-3):283-7. doi: 10.1016/j.jep.2004.05.021. PMID: 15325732.

[6] Bomfim LM, Menezes LR, Rodrigues AC, Dias RB, Rocha CA, Soares MB, Neto AF, Nascimento MP, Campos AF, Silva LC, Costa EV, Bezerra DP. Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):208-13. doi: 10.1111/bcpt.12488. Epub 2015 Oct 6. PMID: 26348780.

Limonene

Limonene is a terpene commonly found in the peels of citrus fruits like lemons, limes, and oranges, as well as in cannabis flowers, spruce trees, and other plants. It is commonly used in foods, beverages, fragrances, cleaners, and cosmetics due to its pungent sweet citrusy aroma. It has been identified in peer-reviewed research as inducing anti-stress[1], anti-anxiety,[2] anti-depressant,[3] and anti-inflammatory (in the airways)[4]^,[5] effects in mouse models. It has also been identified as having antioxidant[6] and anti-cancer[7] properties in human trials and has been identified as a potential muscle relaxant[8] and relaxation aid[9]. When combined, these properties may implicate limonene as being helpful in the treatment of those suffering from related symptoms due to Qualifying Conditions.

[1] Komiya, M., Takeuchi, T. & Harada, E. “Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice.” Behavioural Brain Research 172, 240–249, DOI:10.1016/j.bbr.2006.05.006 (2006)

[2] Song Y, Seo S, Lamichhane S, Seo J, Hong JT, Cha HJ, Yun J. Limonene has anti-anxiety activity via adenosine A2A receptor-mediated regulation of dopaminergic and GABAergic neuronal function in the striatum. Phytomedicine. 2021 Mar;83:153474. doi: 10.1016/j.phymed.2021.153474. Epub 2021 Jan 21. PMID: 33548867.

[3] Lorigooini Z, Boroujeni SN, Sayyadi-Shahraki M, Rahimi-Madiseh M, Bijad E, Amini-Khoei H. Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress. Behav Neurol. 2021 Jan 29;2021:8817309. doi: 10.1155/2021/8817309. PMID: 33564342; PMCID: PMC7864762.

[4] Ryoji Hirota, Hiroyuki Nakamura, Sabah Asif Bhatti, Nlandu Roger Ngatu, Basilua Andre Muzembo, Narongpon Dumavibhat, Masamitsu Eitoku, Masayoshi Sawamura & Narufumi Suganuma (2012)“Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinaetreated mice.”Inhalation Toxicology 24:6, 373-381, DOI:10.3109/08958378.2012.675528 (2012)

[5] Patel, M., Narke, D., Kurade, M. et al. Limonene-induced activation of A2A adenosine receptors reduces airway inflammation and reactivity in a mouse model of asthma. Purinergic Signalling 16, 415–426 (2020). https://doi.org/10.1007/s11302-020-09697-z

[6] Crowell, P. L. & Gould, M. N. “Chemoprevention and Therapy of Cancer by d-Limonene.” Critical Reviews™ in Oncogenesis 5,1–22, DOI:10.1615/CritRevOncog.v5.i1.10 (1994).

[7] Chebet JJ, Ehiri JE, McClelland DJ, Taren D, Hakim IA. Effect of d-limonene and its derivatives on breast cancer in human trials: a scoping review and narrative synthesis. BMC Cancer. 2021 Aug 6;21(1):902. doi: 10.1186/s12885-021-08639-1. PMID: 34362338; PMCID: PMC8349000.

[8] do Vale TG, Furtado EC, Santos JG Jr, Viana GS. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) n.e. Brown. Phytomedicine. 2002 Dec;9(8):709-14. doi: 10.1078/094471102321621304. PMID: 12587690.

[9] Joung, D., et al. “Physiological and Psychological Effects of Olfactory Stimulation with D-Limonene.” Advances in Horticultural Science, vol. 28, no. 2, 2014, pp. 90–94. JSTOR, http://www.jstor.org/stable/24586803. Accessed 1 Nov. 2022.

Myrcene

As one of the most common terpenes present in the cannabis plant, myrcene can be found in cultivars worldwide. Often used as an additive in food manufacturing, myrcene can also be found naturally in mangos, lemongrass, and bay leaves. Various studies on animal models have shown some promising applications for this terpene, including sedation[1], muscle relaxation[2], anti-inflammation[3], and overall pain relief[4]. Analyses of essential oils high in myrcene content have also indicated the possible antioxidant[5] and anti-ulcer[6] properties of this terpene. Furthermore, research on mouse models has demonstrated the potential of this terpene to treat ischemic stroke, due to its neuro[7] and cardiac[8] protective effects.

[1] 78. Freitas JC, Presgrave OA, Fingola FF, Menezes MA, Paumgartten FJ. Effect of beta-myrcene on pentobarbital sleeping time. Braz J Med Biol Res. (1993) 26:519–23. [PubMed] [Google Scholar] [Ref list]

[2] do Vale TG, Furtado EC, Santos JG Jr, Viana GS. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) n.e. Brown. Phytomedicine. 2002 Dec;9(8):709-14. doi: 10.1078/094471102321621304. PMID: 12587690.

[3] McDougall, J.J.; McKenna, M.K. Anti-Inflammatory and Analgesic Properties of the Cannabis Terpene Myrcene in Rat Adjuvant Monoarthritis. Int. J. Mol. Sci. 2022, 23, 7891. https://doi.org/10.3390/ijms23147891

[4] Paula-Freire LI, Molska GR, Andersen ML, Carlini EL. Ocimum gratissimum Essential Oil and Its Isolated Compounds (Eugenol and Myrcene) Reduce Neuropathic Pain in Mice. Planta Med. 2016 Feb;82(3):211-6. doi: 10.1055/s-0035-1558165. Epub 2015 Nov 19. PMID: 26584457.

[5] Ojeda, Adriana & Van Baren, Catalina & Elechosa, Miguel & Juárez, Miguel & Moreno, Silvia. (2013). New insights into antibacterial and antioxidant activities of rosemary essential oils and their main components. Food Control. 31. 189–195. 10.1016/j.foodcont.2012.09.022.

[6] Bonamin F, Moraes TM, Dos Santos RC, Kushima H, Faria FM, Silva MA, Junior IV, Nogueira L, Bauab TM, Souza Brito AR, da Rocha LR, Hiruma-Lima CA. The effect of a minor constituent of essential oil from Citrus aurantium: the role of β-myrcene in preventing peptic ulcer disease. Chem Biol Interact. 2014 Apr 5;212:11-9. doi: 10.1016/j.cbi.2014.01.009. Epub 2014 Jan 27. PMID: 24480520.

[7] Ciftci O, Oztanir MN, Cetin A. Neuroprotective effects of β-myrcene following global cerebral ischemia/reperfusion-mediated oxidative and neuronal damage in a C57BL/J6 mouse. Neurochem Res. 2014 Sep;39(9):1717-23. doi: 10.1007/s11064-014-1365-4. Epub 2014 Jun 28. PMID: 24972849.

[8] Burcu GB, Osman C, Aslı C, Namik OM, Neşe BT. The protective cardiac effects of Β-myrcene after global cerebral ıschemia/reperfusion in C57BL/J6 mouse. Acta Cir Bras. 2016 Jul;31(7):456-62. doi: 10.1590/S0102-865020160070000005. PMID: 27487280.

Pinene

Pinene is unique in that it has two main isomers, alpha and beta, that are both common in the cannabis plant. These isomers have the same molecular composition but different arrangements and are usually notated as α-pinene and β-pinene. As its name suggests, this terpene has a piney aroma and is abundant in most conifers. Pinene can be found in a large variety of plants, including rosemary, parsley, dill and—not surprisingly—pine trees! Various animal studies have demonstrated that pinene may exhibit gastroprotective[1], anxiolytic[2], and anticonvulsant[3] properties, as well as the potential to improve sleep quality[4]. In addition, some animal and in vitro studies have implicated this terpene as a potential treatment for various neurodegenerative diseases[5], including Alzheimer’s[6] and Parkinson’s Disease[7], due to its neuroprotective properties[8]. In vitro research, including studies on essential oils rich in pinene, has shown that pinene may display antioxidant[9], anti-inflammatory[10], antimicrobial[11] effects. Finally, as with several other terpenes, pinene has been linked to anti-tumor[12] and anti-cancer[13] activity.

[1] Pinheiro Mde A, Magalhães RM, Torres DM, Cavalcante RC, Mota FS, Oliveira Coelho EM, Moreira HP, Lima GC, Araújo PC, Cardoso JH, de Souza AN, Diniz LR. Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species. Pharmacogn Mag. 2015 Jan-Mar;11(41):123-30. doi: 10.4103/0973-1296.149725. PMID: 25709221; PMCID: PMC4329611.

[2] Kasuya H, Okada N, Kubohara M, Satou T, Masuo Y, Koike K. Expression of BDNF and TH mRNA in the brain following inhaled administration of α-pinene. Phytother Res. 2015 Jan;29(1):43-7. doi: 10.1002/ptr.5224. Epub 2014 Sep 17. PMID: 25230317.

[3] Felipe CFB, Albuquerque AMS, de Pontes JLX, de Melo JÍV, Rodrigues TCML, de Sousa AMP, Monteiro ÁB, Ribeiro AEDS, Lopes JP, de Menezes IRA, de Almeida RN. Comparative study of alpha- and beta-pinene effect on PTZ-induced convulsions in mice. Fundam Clin Pharmacol. 2019 Apr;33(2):181-190. doi: 10.1111/fcp.12416. Epub 2018 Oct 25. PMID: 30230028.

[4] Yang H, Woo J, Pae AN, Um MY, Cho NC, Park KD, Yoon M, Kim J, Lee CJ, Cho S. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539. doi: 10.1124/mol.116.105080. Epub 2016 Aug 29. PMID: 27573669.

[5] Porres-Martínez M, González-Burgos E, Carretero ME, Gómez-Serranillos MP. In vitro neuroprotective potential of the monoterpenes α-pinene and 1,8-cineole against H2O2-induced oxidative stress in PC12 cells. Z Naturforsch C J Biosci. 2016;71(7-8):191-9. doi: 10.1515/znc-2014-4135. PMID: 27352445.

[6] Lee GY, Lee C, Park GH, Jang JH. Amelioration of Scopolamine-Induced Learning and Memory Impairment by α-Pinene in C57BL/6 Mice. Evid Based Complement Alternat Med. 2017;2017:4926815. doi: 10.1155/2017/4926815. Epub 2017 Nov 1. PMID: 29234406; PMCID: PMC5687139.

[7] Srivastava R, Choudhury PK, Dev SK, Rathore V. Neuroprotective effect of α-pinene self-emulsifying nanoformulation against 6-OHDA induced neurotoxicity on human SH-SY5Y cells and its in vivo validation for anti-Parkinson’s effect. J Biochem Mol Toxicol. 2021 Nov;35(11):e22902. doi: 10.1002/jbt.22902. Epub 2021 Aug 31. PMID: 34464010.

[8] Khoshnazar M, Parvardeh S, Bigdeli MR. Alpha-pinene exerts neuroprotective effects via anti-inflammatory and anti-apoptotic mechanisms in a rat model of focal cerebral ischemia-reperfusion. J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104977. doi: 10.1016/j.jstrokecerebrovasdis.2020.104977. Epub 2020 Jun 13. PMID: 32689608.

[9] Porres-Martínez M, González-Burgos E, Carretero ME, Gómez-Serranillos MP. In vitro neuroprotective potential of the monoterpenes α-pinene and 1,8-cineole against H2O2-induced oxidative stress in PC12 cells. Z Naturforsch C J Biosci. 2016;71(7-8):191-9. doi: 10.1515/znc-2014-4135. PMID: 27352445.

[10] Rufino AT, Ribeiro M, Judas F, Salgueiro L, Lopes MC, Cavaleiro C, Mendes AF. Anti-inflammatory and chondroprotective activity of (+)-α-pinene: structural and enantiomeric selectivity. J Nat Prod. 2014 Feb 28;77(2):264-9. doi: 10.1021/np400828x. Epub 2014 Jan 23. PMID: 24455984.

[11] Rodrigues KA, Amorim LV, Dias CN, Moraes DF, Carneiro SM, Carvalho FA. Syzygium cumini (L.) Skeels essential oil and its major constituent α-pinene exhibit anti-Leishmania activity through immunomodulation in vitro. J Ethnopharmacol. 2015 Feb 3;160:32-40. doi: 10.1016/j.jep.2014.11.024. Epub 2014 Nov 25. PMID: 25460590.

[12] Chen W, Liu Y, Li M, Mao J, Zhang L, Huang R, Jin X, Ye L. Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest. J Pharmacol Sci. 2015 Mar;127(3):332-8. doi: 10.1016/j.jphs.2015.01.008. Epub 2015 Feb 7. PMID: 25837931.

[13] Jo H, Cha B, Kim H, Brito S, Kwak BM, Kim ST, Bin BH, Lee MG. α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway. Int J Mol Sci. 2021 Jan 11;22(2):656. doi: 10.3390/ijms22020656. PMID: 33440866; PMCID: PMC7826552.

Terpinolene

Terpinolene is found in a wide variety of plants and spices, including nutmeg, parsnips, cardamom, apples, cumin, and lilacs. The aroma profile of this terpene reflects this variety and can be described as a mix of floral, woodsy, sweet, and herbaceous. Due to its ‘fresh’ aroma, terpinolene is often used as an additive in cosmetic and household cleaning products. Several studies have investigated the effects of this terpene using essential oils (most notably tea tree oil) that are rich in terpinolene. Results suggest that this terpene may provide antioxidant[1]^,[2] and anti-bacterial[3] properties. In addition, animal models have demonstrated the sedative[4] effects of this terpene, as well as its potential to treat pain, inflammation[5], and even cancer[6].

[1] J Grassmann, S Hippeli, R Spitzenberger, E F Esltner. The monoterpene terpinolene from the oil of Pinus mugo L. in concert with alpha-tocopherol and beta-carotene effectively prevents oxidation of LDL. Phytomedicine 2005 Jun;12(6-7):416-23. doi: 10.1016/j.phymed.2003.10.005

[2] Kim HJ, Chen F, Wu C, Wang X, Chung HY, Jin Z. Evaluation of antioxidant activity of Australian tea tree (Melaleuca alternifolia) oil and its components. J Agric Food Chem. 2004 May 19;52(10):2849-54. doi: 10.1021/jf035377d. PMID: 15137824.

[3] Mazandarani, M. & Mirdeilami, Z. & Pessarakli, Mohammad. (2013). Essential oil composition and antibacterial activity of Achillea millefolium L. from different regions in North east of Iran. J. Med. Plants Res.. 7. 1063-1069.

[4] Ken Ito, Michiho Ito. The sedative effect of inhaled terpinolene in mice and its structure-activity relationships. Journal of Natural Medicines 2013 Oct;67(4):833-7. DOI: 10.1007/s11418-012-0732-1. Epub 2013 Jan 22.

[5] Macedo, E. et al. “Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation.” Brazilian Journal of Medical and Biological Research 49.7, DOI:10.1590/1414-431×20165103 (2016)

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